Nucro-Technics offers a broad array of in vitro ADME services that cover a wide array of laboratory experiments used to evaluated the Absorption, Distribution, Metabolism, and Excretion (ADME) properties of drug candidates throughout the drug development process. These studies are conducted in order to better understand the properties and characteristics of a drug candidate. Although they are typically performed earlier on during the drug development life cycle, they can be performed at any time from the discovery, IND-Enabling, clinical trial, or new drug application stage.

Operating for more than 50 years, Nucro-Technics’ team of seasoned scientists employs state-of-the-art techniques and platforms to deliver precise and insightful in vitro ADME data, essential for the optimization of drug candidates. Our services cater to pharmaceutical and biotechnology companies seeking to understand the pharmacokinetic properties of their compounds in a cost-effective and timely manner.

The services performed by this department include, but are not limited to:

• Hepatocyte Stability and Metabolite Profiling
• Cytochrome P450 Phenotyping by chemical inhibition
• Cytochrome P450 Phenotyping with recombinant CYPs
• Protein Binding Assays
• Platelet Activation Assays
• Hemolytic Potential Assessments / Hemolysis Testing
• In vitro Deglucoronidation